Summary This paper presents an analysis and discussion of the opinions of two generations of Asian parents with regard to their young children's education. A large number of parents (n = 200) were interviewed during 1970-1974 and a smaller number (n = 40) during 1995 to ascertain their views on a variety of topics relating to their children's early education. The findings are discussed in a qualitative way and reveal the increasing satisfaction of Asian parents with their children's education. A (...) higher proportion of the mothers of the 1990s help their children with homework, read them stories and are generally more participatory in their children's education compared with the 1970s group. The second generations are concerned with the lack of facilities for the teaching of mother tongues in schools. These and other findings are discussed within the changing lifestyles of second-generation Asians. (shrink)

This paper presents an analysis and discussion of the opinions of two generations of Asian parents with regard to their young children's education. A large number of parents were interviewed during 1970-1974 and a smaller number during 1995 to ascertain their views on a variety of topics relating to their children's early education. The findings are discussed in a qualitative way and reveal the increasing satisfaction of Asian parents with their children's education. A higher proportion of the mothers of the (...) 1990s help their children with homework, read them stories and are generally more participatory in their children's education compared with the 1970s group. The second generations are concerned with the lack of facilities for the teaching of mother tongues in schools. These and other findings are discussed within the changing lifestyles of second-generation Asians. (shrink)

© Copyright 2015, Mary Ann Liebert, Inc..Signal transducer and activator of transcription factor 3 is hyperactivated in head and neck squamous cell carcinomas. Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progression and drug resistance. A library of 94,491 compounds from the Molecular Library Screening Center Network was screened for the ability to inhibit interleukin-6 -induced pSTAT3 activation. For contractual reasons, the primary high-content screening campaign was (...) conducted over several months in 3 distinct phases; 1,068 primary HCS actives remained after cytotoxic or fluorescent outliers were eliminated. One thousand one hundred eighty-seven compounds were cherry-picked for confirmation; actives identified in the primary HCS and compounds selected by a structural similarity search of the remaining MLSCN library using hits identified in phases I and II of the screen. Actives were confirmed in pSTAT3 IC50 assays, and an IFNγ-induced pSTAT1 activation assay was used to prioritize selective inhibitors of STAT3 activation that would not inhibit STAT1 tumor suppressor functions. Two hundred three concentration-dependent inhibitors of IL-6-induced pSTAT3 activation were identified and 89 of these also produced IC50s against IFN-γ-induced pSTAT1 activation. Forty-nine compounds met our hit criteria: they reproducibly inhibited IL-6-induced pSTAT3 activation by ≥70% at 20 μM; their pSTAT3 activation IC50s were ≤25 μM; they were ≥2-fold selective for pSTAT3 inhibition over pSTAT1 inhibition; a cross target query of PubChem indicated that they were not biologically promiscuous; and they were ≥90% pure. Twenty-six chemically tractable hits that passed filters for nuisance compounds and had acceptable drug-like and ADME-Tox properties by computational evaluation were purchased for characterization. The hit structures were distributed among 5 clusters and 8 singletons. Twenty-four compounds inhibited IL-6-induced pSTAT3 activation with IC50s ≤20 μM and 13 were ≥3-fold selective versus inhibition of pSTAT1 activation. Eighteen hits inhibited the growth of HNSCC cell lines with average IC50s ≤ 20 μM. Four chemical series were progressed into lead optimization: the guanidinoquinazolines, the triazolothiadiazines, the amino alcohols, and an oxazole-piperazine singleton. (shrink)

In this paper, the authors explore the question of whether cognitive enhancement via direct neurostimulation, such as through deep brain stimulation, could be reasonably characterized as a form of transformative experience. This question is inspired by a qualitative study being conducted with people at risk of developing dementia and in intimate relationships with people living with dementia (PLWD). They apply L.A. Paul’s work on transformative experience to the question of cognitive enhancement and explore potential limitations on the kind of (...) claims that can legitimately be made about individual well-being and flourishing, as well as limit the kind of empirical work—including the authors’ own—that can hope to enlighten ethical discourse. In this paper, the authors advance the following theses: (1) it is sometimes reasonable to characterize cognitive enhancement as a transformative experience; (2) the testimonies of people intimately acquainted with dementia may still be relevant to evaluating cognitive enhancement even though cognitive enhancement may be a transformative experience; and (3) qualitative studies may still be useful in the ethical analysis of cognitive enhancement, but special attention may need to be given to how these are conducted and what kind of insights can be drawn from them. (shrink)

Riddles of induction – old or new, Hume’s or Goodman’s – pose unanswered challenges to assumptions that experiences logically legitimate expectations or classifications. The challenges apply both to folk beliefs and to scientific ones. In particular, Goodman’s ‘new riddle’ famously confounds efforts to specify how additional experiences confirm the rightness of currently preferred ways of organizing objects, i.e. our favored theories of what kinds there are.1 His riddle serves to emphasize that neither logic nor experience certifies accepted groupings of objects (...) into kinds.2 Hacking strongly endorses Goodman’s riddle and its chief consequences – nature does not dictate any organizing scheme to us, and different schemes need have no connection to one another. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 62.2 (2001) 233-244 [Access article in PDF] Joseph Butler on Forgiveness: A Presupposed Theory of Emotion Paul A. Newberry "I forgive him as far as humanity can forgive. I would do him no injury." Mrs. Dale in Anthony Trollope's The Last Chronicle of Barset, 1867. In the recent philosophical literature on forgiveness, a topic of great concern is the proper characterization of (...) forgiveness or, said in another way, the proper definition of forgiveness. Forgiveness has been defined in a multitude of ways: among others, as the overcoming of resentment, the overcoming of moral hatred, as a speech act, and as forbearance. Of these definitions the one that enjoys anything close to a kind of consensus is that forgiveness is the overcoming of resentment. This position, with various qualifications and stipulations, is held by numerous philosophers, among them R. S. Downie, Kathleen Dean Moore, A. C. Ewing, Martin Hughes, and Jeffrie Murphy. 1 The progenitor of this view is widely acknowledged to be Joseph Butler, who wrote sermons on both resentment and forgiveness nearly three hundred years ago. 2In this paper I will demonstrate that the attribution of this definition of forgiveness to Butler is in error: he did not define forgiveness as the overcoming of resentment but rather as the checking of revenge, or forbearance. Aside from the goal of setting the historical record straight, I have a broader and more important purpose in this essay. One sees that such an interpretation of Butler must provoke two questions. First, why did Butler define forgiveness only in terms of how one is to act, therefore paying no attention, apparently, to how one feels? Second, how do Murphy and the others incorrectly attribute this view to Butler? [End Page 233] I contend that these answers can be addressed if we take a close look at the role of emotions and theories of emotion in the definitions offered by Butler and Murphy (as representative of the group). I will attempt to establish that Butler's definition of forgiveness as the checking of revenge presupposes a feeling theory of emotions which is distinct from and in conflict with--in many ways pertinent to forgiveness--the cognitive theory of emotions presupposed by Murphy's definition. If I am successful in showing this claim to be plausible, then I will also have demonstrated that more attention needs to be paid to theories of emotion underlying work on forgiveness. But since the misinterpretation of Butler is widespread among contemporary writers on forgiveness and not peculiar to Murphy, my claim is a gesture toward what I take to be a problem greater than mere misinterpretation. Given the fact that a feeling theory of emotions was the predominant theory among philosophers in Butler's day until the end of the nineteenth century and that cognitive theory is currently a dominant philosophical theory, I fear that what has happened is that modern commentators on Butler are unaware that they are imposing their own presupposed theories of emotion onto a text from an earlier historical period.The plan of the paper is first to show by careful exegesis how Butler characterizes forgiveness and then, after a brief sketch of the difference between feeling theory and cognitive theory, to demonstrate how Butler's definition presupposes the former and Murphy's the latter. I will conclude with a few remarks about the import of these findings.Joseph Butler's treatment of forgiveness is found in a collection of his sermons first published as Fifteen Sermons in 1726. 3 Included in this collection are two sermons of primary importance to the topic of forgiveness: a sermon on resentment (Sermon VIII) and a subsequent sermon on forgiveness (Sermon IX). An understanding of Butler's definition of forgiveness properly begins with his sermon on resentment in which he distinguishes between two different kinds of resentment. One kind he calls "hasty and sudden" resentment, the other "settled and deliberate" resentment. 4 Hasty and sudden resentment is generally (and naturally) the result of sudden hurt or violence. 5... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Slipping on Banana Peels, Tumbling into WellsPhilosophy and ComedyPaul A. Kottman (bio)Alenka Zupančič. The Odd One In: On Comedy. Cambridge, MA: MIT P, 2008.[T]he philosopher... is the jest, not only of Thracian handmaids but of the general herd, tumbling into wells and every sort of disaster through his inexperience [hupo apeirias].—Plato, Theaetetus 174cWhy stop philosophy’s most precious intrinsic comedy when it comes to comedy?—Alenka Zupančič, The Odd One In1“Comedy,” (...) writes Alenka Zupančič in The Odd One In, “draws our attention to the fact that something of our life lives on its own as we speak, that is to say, at any moment of our life” [218]. Reelaborating some of Jacques Lacan’s formulations regarding comedy, drive, and desire, Zupančič clarifies that this “something” is the “Real of human desire”— namely, “the incongruence of the reality of desire and drive with all those (also quite factual) outlines that determine our supposedly realistic reality” [218]. This extrapolation from Lacan frames Zupančič’s views on comedy and its subversive character; but it is her unique engagement with G. W. F. Hegel’s remarks on comedy—particularly the sections of the Phenomenology of Spirit in which Hegel tracks the passage from the Comedy of Aristophanes to Christianity—that give a distinctive arc to Zupančič’s highly original and generative approach to comedy and its subversive character. In this review essay, I will draw attention to some of the most original aspects of this critical appropriation of Hegel, while highlighting key elements of the text’s argumentative trajectory. Toward the end of this essay, I will also suggest ways that Hegel’s speculative remarks, which see the comic figure as symptomatic of a community that is not yet conscious of itself as such, might allow us to put into question some of Zupančič’s central claims regarding the subversive nature of both comedy and her own critical intervention.Zupančič’s reflections on comedy—which are not only innovative, but also delightfully readable—merit, in their own right, the attention of anyone interested in the intersection of literature, philosophy, and contemporary culture; but her text is all the more significant in light of the oft-remarked rarity of sustained philosophical reflections on comedy. Although there are a number of books on comedy as a literary genre, philosophical studies of comedy are surprisingly rare.1 Henri Bergson’s Le rire (published in 1900) [End Page 3] is perhaps the most well known. More recently, Simon Critchley has written about laughter, wit, and jokes in On Humour. Perhaps the most comprehensive philosophical account of comedy to date—Agnes Heller’s Immortal Comedy: The Comic Phenomenon in Art, Literature and Life (2005)—was published only three years before The Odd One In.2In contrast to Heller’s work, which offers a philosophical account of a variety of comic works and genres, and unlike these other earlier studies, which deal with the poetics of comedy and related phenomena such as laughter or jokes, Zupančič does not approach comedy as an object of inquiry that might be analyzed by philosophical categories or methods, nor even as a phenomenon that is extrinsic to philosophy. Instead, she sees comedy and philosophy as intrinsic to one another, such that the fate of philosophical activity is tied to the fate of the comical. In assessing Zupančič’s claims, therefore, I will strive less for a summary catalogue of the claims presented in the book than for a reelaboration of what I take to be her most provocative and important assertions regarding what she calls the “critical edge” shared by both philosophy and comedy [Zupančič 9].The Odd One In is the eighth title in the series Short Circuits, edited by Slavoj Žižek, in relation to whose writings Zupančič’s text clearly stands in intellectual and stylistic propinquity. (Žižek himself might be taken as a prime figure in whom comic and philosophical practices, in Zupančič’s sense, coincide.) The book opens and closes with a reminder that we too often mistake the subversive side of comedy for “a consolation... (shrink)

Charles-Louis de Secondat, baron de La Brède et de Montesquieu, mentions Niccolò Machiavelli by name in his extant works just a handful of times. That, however, he read him carefully and thoroughly time and again there can be no doubt, and it is also clear that he couches his argument both in his Considerations on the Causes of the Greatness of the Romans and their Decline and in his Spirit of Laws as an appropriation and critique of the work of (...) the predecessor whom he termed ‘this great man’. In this paper I explore the manner in which the Frenchman redeployed the arguments advanced by the Florentine for the purpose of refuting the latter's conclusions. ☆ In citing Machiavelli, I employ N. Machiavelli, Tutte le opere, ed. M. Martelli (Florence, 1971), and I refer to the divisions within each work provided by the author. To make my references to Machiavelli's Discorsi sopra la prima deca di Tito Livio more precise, I sometimes also employ the paragraph enumeration added by the editors of N. Machiavelli, Discourses on Livy, tr. H. C. Mansfield and N. Tarcov (Chicago, 1996). In citing Montesquieu, wherever possible, I have employed the splendid new critical edition being produced by the Société Montesquieu: Charles-Louis de Secondat, baron de La Brède et de Montesquieu, Œuvres complètes de Montesquieu, ed. J. Ehrard, C. Volpilhac-Auger, et al., 22 vols. (Oxford, 1998-), which I cite as VF. I cite Montesquieu, Considérations sur les causes de la grandeur des Romains et de leur décadence (1734), ed. F. Weil and C. Courtney, as CR by chapter and, where appropriate, line from VF, ii, 89–285. I cite Montesquieu, De l’Esprit des lois (1757), as EL by part, book, chapter, and, where appropriate, page from Montesquieu, Œuvres complètes de Montesquieu, ed. R. Caillois, 2 vols. (Paris, 1949–51), ii, 225–995, and Charles-Louis de Secondat, baron de La Brède et de Montesquieu, Mes pensées as MP by number from Montesquieu, Œuvres complètes de Montesquieu, ed. A. Masson, 3 vols. (Paris, 1950–5), ii, 1–677. (shrink)

PETRIVERSE. Noun.1) A world composed of rocks; e.g., a rock garden.2) Words composed of rocks; i.e., verse written in stone.The Petriverse of Pierre Jardin is a born-digital work of speculative theory that documents a decade of work on stone in a variety of media, from collecting cobble and composing displays in a contemplative rock garden, to conducting research, traveling, and photographing and writing about stones. This work has been undertaken as an apprenticeship to stone, in Deleuze's sense of apprenticeship of (...) a process in which "to learn is first of all to consider a substance…as if it emitted signs to be deciphered, interpreted. … One becomes a carpenter only by becoming sensitive to the signs of wood"... (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Scholars have long noted Ignatius of Antioch’s statements of high christology. Jesus, who as God appeared in human form, is ‘God in man’ and is ‘our God’. Jesus Christ is included in such ‘nas-cent trinitarian’ passages as Eph. 9.1 and Magn. 13.1-2. Yet further treasures remain to be mined, and the specific vein I will explore is the integration of Ignatius’ high christology with his ethics. His paraenesis is rooted in ‘the mind of God’, also described as ‘the mind of (...) Christ’, who is ‘the God who made you so wise’. Ignatian moral instruction combines ‘the will of God and Jesus Christ’, ‘the honor of the Father and the honor of Jesus Christ’, and ‘the love of God the Father and the Lord Jesus Christ’. Believers are to be ‘imitators of God’ as well as ‘imitators of Jesus Christ’. Ignatius even prayed that he would be ‘an imitator of the suffering of my God’. Ignatian exhortation thus merges an imitatio Christi with an imitatio Dei. Arising from his particular experiences and specific circumstances, Ignatius’ contextualized paraenesis elevates the Son to an authoritative status parallel to that of the Father. The interplay of christology and ethics also underscores a multi-leveled understanding of ‘unity’ and a multivalent use of ‘flesh and spirit’. (shrink)

Quine is usually read as arguing either for a non-factualism about analyticity (1) ... Or, at the very least, for an error thesis about it: (2) ... These attributions — including the stronger non-factualist thesis — seem licensed by many passages, including the famous one which concludes Quine's discussion in "Two Dogmas" ... Nevertheless, Paul Horwich does not wish to read Quine as endorsing either (1) or (2). He certainly does not wish to attribute (1) to him. And he (...) wishes to attribute only a restricted version of (2). What this restriction is and why Paul wants to make it are matters I'll come to in just a moment. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Breathing with Mountains1Paul A. Harris (bio)For Sydney Levy, who brought me on board.Geologic AspirationsStone breathes within nature's time cycle…. It begins before you and continues through you and goes on. Working with stone is not resisting time but touching it.—Isamu NoguchiUnder the suffocating circumstances of lockdown, COVID conditions inevitably wafted their way into the stoned thinking of Pierre Jardin.2 The pandemic atmosphere made air apparent, and breathing became personal, (...) political, and planetary. People sought perspective in sometimes surprising ways. While many turned to the Stoics, Jardin turned to stone. Suspending his disbelief in "The Hammock of Relaxation" (fig. 1), Jardin stretched his imagination, and set himself adrift in diffuse reveries of rocky respiration. Click for larger view View full resolutionFigure 1.The Hammock of Relaxation. Pebble on book cover.Photo by author.Jardin composes a life centered in absorbing stone(s), encompassing both a physical process of soaking in a substance slowly and psychological experience of becoming engrossed in it. He feels alive with stone and stone alive in him; literally and metaphorically, he has spent hours looking at stone, listening to stone, and touching/being touched by stone. But he had never seriously considered breathing stone. Immediately, a slew of questions arose: Do rocks breathe? Do mountains? Does the Earth? What would it mean to breathe with a stone, or with the planet? Jardin's pursuit of lithic and lithospheric respirations came to comprise his geologic aspirations, which are set out here. [End Page 261]Aerial ImaginationPierre Jardin's geologic aspirations took inspiration from Gaston Bachelard's aerial imagination, as described in Air and Dreams. Accepting Bachelard's invitation to "listen to nothing but our own breathing…, to become as aerial as our breath…" (Bachelard, Air 241), Jardin set about inventing a regimen of contemplative breathing exercises. To do so, he took up what Bachelard terms the "search for a thought hidden under expressive sedimen,ts, [in which] a geology of silence is developed" (Bachelard Air, 251). The question was, what "expressive sediments" should Jardin mine in this quixotic quest? What materials and mental modalities would precipitate a "geology of silence"?In order to meld minds with Bachelard, Jardin placed a pebble on Robert Lapoujade's pencil portrait that graces the book's cover (fig. 2). The results were alchemical: the cobble transmuted into a philosopher's stone, opening Bachelard's third eye; the rock launched a basalt on Jardin's senses that produced an "intoxication of aerial imagination raised to its cosmic role" (Bachelard, Air 241). A gesture as simple as placing a rock on a book crystallized new quartz-veins of thought. What follows are Jardin's experiments with a variety of "expressive sediments," a series of multi-scalar meditations and various instantiations of lithic respiration. Click for larger view View full resolutionFigure 2.Aerial Basalt on the Senses. Pebble on book cover.Photo by author.Atmospheric CompositionsPierre Jardin's geologic aspirations began with a Composition of Place, a meditative technique deployed in the Spiritual Exercises of Ignatius of Loyola. Loyola stipulates that "for contemplation or meditation about visible things… the 'composition' will consist in seeing through the gaze of the imagination the material place where the object I want to contemplate is situated" (Ganss 47). Taking "Breathing with Mountains" as the "object" of contemplation stretches Jardin's imagination to a geologic scale; its "material place" is the Earth's atmosphere, or more specifically, its lowest layer, the troposphere. [End Page 262]To facilitate his meditation, Jardin scales Earth down to a stunning serpentine stone, which he has mounted like a globe. Holding the stone and breathing slowly, Jardin can visualize the troposphere as the thinnest of films on the rock's surface. In his active imagination, the bumps, furrows, and ridges in the rough rock texture evoke the constant crumpling of the lithosphere caused by drifting and crashing tectonic plates.With the stone standing in for Earth, Jardin suddenly becomes a geologic giant representing Anthropocene humanity. As his exhalations cloud the stone, Jardin considers how Anthropogenic expirations are changing the composition of the Earth's atmosphere. An index of human impact is provided... (shrink)

Alex Rosenberg’s latest book purports to establish that narrative history cannot have any epistemic value. Rosenberg argues not for the replacement of narrative history by something more science-like, but rather the end of histories understood as an account of human doings under a certain description. This review critiques three of his main arguments: 1) narrative history must root its explanations in folk psychology, 2) there are no beliefs nor desires guiding human action, and 3) historical narratives are morally and ethically (...) pernicious. Rosenberg’s book reprises themes about action explanation he first rehearsed 40 years ago, albeit with neuroscience rather than sociobiology now “preempting” explanations that trade on folk psychological notions. Although Rosenberg’s argument strategy has not altered, the review develops a number of reasons as to why his approach now lacks any plausibility as a strategy for explaining histories, much less a successful one. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Breaking EarthAlexis Rider (bio) and Paul A. Harris (bio)“He takes all that, the strata and the magma and the people and the power, in his imaginary hands. Everything. He holds it. He is not alone. The earth is with him. Then he breaks it.”― N. K. Jemisin, The Fifth SeasonBreaking Earth, a collection of visual and written essays brought together for this special issue of SubStance, is a (...) disruptive engagement with concepts and terms that have become touchstones for the geologic/planetary turn in the inhumanities. The project took initial inspiration in conversations the co-editors had about N. K. Jemisin’s Broken Earth trilogy, in which geologic and human power interweave in complex webs among bodies born of chiasmic crossings of Anthro-progeny and Geo-orogeny. Conceived as a companion almanac to Jemisin’s trilogy—though references to that work are intentionally oblique—the volume pursues new ways of reading, and being with, the geos of this planet. In doing so, Breaking Earth seeks to reframe and deepen the discussions, both historical and philosophical, around the relationship between geology and humanity.The notion of the Anthropocene has, for several decades, monopolized said discussions. Since its articulation in the early 2000s, the concept has been equal parts galvanizing and problematic in thinking with the Earth (Crutzen). Proposed by an atmospheric chemist, incorporated (with caveats) into the geologic deep time of the planet by geologists, and taken up with vigor by humanists, social scientists, and artists, the Anthropocene has, for better or worse, broken significant new ground in Earth-oriented thought.The term’s core proposals—that humans are a geologic force and we have entered a wholly new period of Earth history—has compelled scholars to engage with a geologic tradition of mapping and classifying the history of said forces along a temporal scale. This tradition—exemplified in the International Chronostratigraphic Chart (ICC) below (Figure 1)—relies on the translation of messiness and difference into abstracted orderly categories of strata and type. Of course, no geologist would claim that the ICC is a direct representation of the materiality of the rocky Earth we live on, so full of faults, fissures, and unconformities. But as writers, [End Page 3] artists, and activists have made clear, the repositioning of humans-as-strata is far riskier than imposing abstract order on a cliff face: it dangerously flattens out the messiness of human history and difference—obfuscating the uneven histories of extraction and oppression to which the mining of geophysical energies and resources is so clearly bound. The Anthropocene has therefore helped reveal the immense pitfalls of conflating a species with the geologic, and made clear the need for humanists—both within the academy and beyond—to develop a language and method for thinking about the changing Earth. Click for larger view View full resolutionFigure 1.International Chronostratigraphic Chart (ICC), International Commission on Stratigraphy, 2023, www.stratigraphy.org.At the same time, the very act of attempting to identify the Anthropocene within stratigraphic nomenclature has usefully challenged old and brittle binaries. Contemporary rhetoric around how to conceive of change—backed often by disciplinary boundary-keeping—exemplifies such divisions. Take, for example, the grammatical distinction between political, social forces and physical, environmental forcings (Hulme). These seemingly inane suffixes recast agency and allow the natural and social worlds to exist in two separate spheres (albeit ones that overlap via extraction) where human action is more wholly filled with intent. Breaking this distinction via a reconceptualization of geologic agency underpins [End Page 4] what scholars, including Pratik Chakrabarti and Kathryn Yusoff, have been articulating so clearly: rocks have politics. To unpack this carefully and fully, however, requires moving beyond the collapse of anthropos into geos: there is too much texture, history, and action lost in such a sweeping and simple formulation.This collection takes these problematics of the Anthropocene as self-evident: it critically engages with the chronostratigraphic logic that implicitly upholds a view of time, history, and knowledge which operationalizes the extractive carbon capital economies fueled by colonialism and slavery. This assertion bears emphasizing, given the announcement from the Anthropocene Working Group (AWG) in the summer of 2023 that the origin of... (shrink)

Modern scholarship on decision behavior dates from the late 1940s. But that scholarship has been preoccupied with two ideas that are much older. One is the notion of expected utility, first articulated in the scholarly literature by Daniel Bernoulli in 1738. In its simplest form, the expected utility concept applies to monetary gambles. Imagine you are asked to choose between two gifts, either gamble G, which you would then play and get either $9 or nothing, or else a simple, direct (...) payment of $3. As shown in the decision tree in figure 10.1, you receive gamble G's $9 payoff if the toss of a fair die yields one or two pips, but you receive nothing otherwise. (In decision trees, choice points are represented by square nodes, chance points by circular nodes.) The expected value or expectation of a gamble is the sum of its payoffs, each weighted (i.e., multiplied) by its probability. Thus, the expected value of G is EV(G) = (1/3)($9) + (2/3)($0) = $3, the same as the direct payment. So, if you generally make decisions like this one so as to maximize expected value, you would be indifferent between the present options. However, if you are like most people, you are not indifferent. Instead, you are risk‐averse, preferring the guaranteed $3. Why? (shrink)

Measuring neuronal activity with electrophysiological methods may be useful in detecting neurological dysfunctions, such as mild traumatic brain injury (mTBI). This approach may be particularly valuable for rapid detection in at-risk populations including military service members and athletes. Electrophysiological methods, such as quantitative electroencephalography (qEEG) and recording event-related potentials (ERPs) may be promising; however, the field is nascent and significant controversy exists on the efficacy and accuracy of the approaches as diagnostic tools. For example, the specific measures derived from an (...) electroencephalogram (EEG) that are most suitable as markers of dysfunction have not been clearly established. A study was conducted to summarize and evaluate the statistical rigor of evidence on the overall utility of qEEG as an mTBI detection tool. The analysis evaluated qEEG measures/parameters that may be most suitable as fieldable diagnostic tools, identified other types of EEG measures and analysis methods of promise, recommended specific measures and analysis methods for further development as mTBI detection tools, identified research gaps in the field, and recommended future research and development thrust areas. The qEEG study group formed the following conclusions: 1. Individual qEEG measures provide limited diagnostic utility for mTBI. However, many measures can be important features of qEEG discriminant functions, which do show significant promise as mTBI detection tools. 2. ERPs offer utility in mTBI detection. In fact, evidence indicates that ERPs can identify abnormalities in cases where EEGs alone are nondisclosing. 3. The standard mathematical procedures used in the characterization of mTBI EEGs should be expanded to incorporate newer methods of analysis including nonlinear dynamical analysis, complexity measures, analysis of causal interactions, graph theory and information dynamics. 4. and 5. are too long to include here. (shrink)

In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount the often‐ugly history of scientific attempts to understand the genetic contributions to human behaviors and social outcomes. They then describe what the current science—including genomewide association studies and polygenic indexes—can and cannot tell us, as well as its risks and potential benefits. They conclude with a discussion of responsible behavior in the context of SBG research. (...) SBG research that compares individuals within a group according to a “sensitive” phenotype requires extra attention to responsible conduct and to responsible communication about the research and its findings. SBG research (1) on sensitive phenotypes that (2) compares two or more groups defined by (a) race, (b) ethnicity, or (c) genetic ancestry (where genetic ancestry could easily be misunderstood as race or ethnicity) requires a compelling justification to be conducted, funded, or published. All authors agree that this justification at least requires a convincing argument that a study's design could yield scientifically valid results; some authors would additionally require the study to have a socially favorable risk‐benefit profile. (shrink)

Periodically, we take stock of SubStance and provide a brief statement regarding initiatives and priorities in the journal's interests. Three years ago, we announced that "Exploring hybrid writing with theoretical impact is at the center of our current preoccupations."1 Since that time, the journal has made significant changes. This issue marks our fourth issue of publishing with Johns Hopkins University Press in a transition that recognizes our new publisher as a leader among university presses.Our plan also expressed our intent to (...) move toward publishing digital work that exemplifies theoretical thinking in nonlinear, experimental forms. In 2018, we launched Digital SubStance, a platform for "hybrid work that... (shrink)

The experience of a reward appears to enhance memory for recent prior events, adaptively making that information more available to guide future decision-making. Here, we tested whether reward enhances memory for associative item-location information and also whether the effect of reward spreads to other categorically-related but unrewarded items. Participants earned either points (Experiment 1) or money (Experiment 2) through a time-estimation reward task, during which stimuli-location pairings around a 2D-ring were shown followed by either high-value or low-value rewards. All stimuli (...) were then tested for location memory or recognition (yes/no), immediately and after a 24-hour delay. Across both experiments (combined analysis), there was a robust improvement in location memory following high-value rewards, even though evidence supporting this effect was reliable in Experiment 2 but not in Experiment 1. The memory-enhancing effect of reward was observed on both the immediate and delayed location-memory tests. Reward-enhanced memory for both directly rewarded stimuli and categorically related stimuli that were not directly rewarded. No reliable effect of reward value on yes/no recognition-memory performance was observed in either experiment. We hypothesise that reward enhances the consolidation of recent experience and conceptually related memories to make these more available for future decisions. (shrink)

Existentialist thinkers often publicly acknowledged Husserl’s phenomenology as one of their main points of departure for treatment of such themes as intentionality, comportment, transcendence, and the lifeworld. Several central elements of Husserl’s approach were adopted by the Existentialists, but equal to their gratitude were vigorous declamations of Husserl’s mistakes, dead-ends and failures. Many of the Existentialists’ criticisms of Husserl’s project are well-known and have been rehearsed in various surveys of 20th century thought, but less well-remarked are the discrepancies between their (...) complaints about Husserl’s aborted achievements and what Husserl actually delivered. This paper attempts to uncover the accuracy of some of their assessments of Husserl’s alleged failures and mistakes, whether or not Husserl actually held the position they claim he did, and especially whether or not Husserl was himself aware of some deficiency in his thematic analysis, and thus would have been able to offer a cogent response to critique. In doing so, a good case can be made that Heidegger, for example, quietly adopted some of Husserl’s main insights without credit, slanted his picture of Husserl’s work so that his own reversals had better purchase, or overlooked evidence that Husserl had already moved beyond that position. At least on some key topics, Husserl emerges as an exceptionally self-critical philosopher who had already gained the perspective more usually associated with an Existentialist orientation. Indo-Pacific Journal of Phenomenology , Volume 1, Edition 1 April 2001. (shrink)

In “What you can’t expect when you’re expecting,” I argue that, if you don’t know what it’s like to be a parent, you cannot make this decision rationally—at least, not if your decision is based on what you think it would be like for you to become a parent. My argument hinges on the idea that becoming a parent is a transformative experience. This unique type of experience often transforms people in a deep and personal sense, and in the process, (...) changes their preferences. In section 1, I will explain transformative experience in terms of radical first-personal epistemic and self change. In section 2, I’ll explain the notion of subjective value that I use to develop the decision problem. In section 3, I will discuss the way we ordinarily combine our introspective assessments with testimony and evidence. In section 4, I will discuss the problems for rational decision-making. In section 5, I will explore the problem of first-personally transformed future selves. In section 6, I will engage with the main themes and arguments and ideas of the authors of the papers contributed to this volume. (shrink)

© 2016 Elsevier LtdJumping spiders are famous for their visually driven behaviors [1]. Here, however, we present behavioral and neurophysiological evidence that these animals also perceive and respond to airborne acoustic stimuli, even when the distance between the animal and the sound source is relatively large and with stimulus amplitudes at the position of the spider of ∼65 dB sound pressure level. Behavioral experiments with the jumping spider Phidippus audax reveal that these animals respond to low-frequency sounds by freezing—a common (...) anti-predatory behavior characteristic of an acoustic startle response. Neurophysiological recordings from auditory-sensitive neural units in the brains of these jumping spiders showed responses to low-frequency tones —recordings that also represent the first record of acoustically responsive neural units in the jumping spider brain. Responses persisted even when the distances between spider and stimulus source exceeded 3 m and under anechoic conditions. Thus, these spiders appear able to detect airborne sound at distances in the acoustic far-field region, beyond the near-field range often thought to bound acoustic perception in arthropods that lack tympanic ears [2]. Furthermore, direct mechanical stimulation of hairs on the patella of the foreleg was sufficient to generate responses in neural units that also responded to airborne acoustic stimuli—evidence that these hairs likely play a role in the detection of acoustic cues. We suggest that these auditory responses enable the detection of predators and facilitate an acoustic startle response. Video. (shrink)

An investigation is presented in which a computer simulation model (DIAGNOSER) is used to develop and test predictions for behavior of subjects in a task of medical diagnosis. The first experiment employed a process‐tracing methodology in order to compare hypothesis generation and evaluation behavior of DIAGNOSER with individuals at different levels of expertise (students, trainees, experts). A second experiment performed with only DIAGNOSER identified conditions under which errors in reasoning in the first experiment could be related to interpretation of specific (...) data items. Predictions derived from DIAGNOSER's performance were tested in a third experiment with a new sample of subjects. Data from the three experiments indicated that (1) form of diagnostic reasoning was similar for all subjects trained in medicine and for the simulation model, (2) substance of diagnostic reasoning employed by the simulation model was parable with that of the more expert subjects, and (3) errors in subjects' reasoning were attributable to deficiencies in disease knowledge and the interpretation of specific patient data cues predicted by the simulation model. (shrink)

P¯an.ini’s grammar includes several types of metarules which determine how its operational rules apply. Among them are “traffic rules” which constrain how rules interact with each other in grammatical derivations. These are typically formulated as designating a rule or class of rules asiddha “not effected” (or asiddhavat “as if not effected”) with respect to another rule or class of rules. For economy, the rules so designated are grouped into several sections, whose headings collectively declare them to be asiddha(vat). The biggest (...) such section, under the famous heading 8.2.1 p ¯urvatr¯asiddham, extends from 8.2.1 through the end of the grammar (8.4.68), and is hence called the Trip¯ad¯ı ‘Three Sections’. (shrink)

This study attempts to refine and test a theory of social influences on ethical decisions of journalists. The theoretical model proposes that several social factors influence any given decision, and that a hierarchy of influences assigns relative value to each: individual, small group, organization, competition, occupation, extramedia, and law. Print and broadcast journalists reacted to 3 hypothetical scenarios that raised ethical problems. The journalists then rated the salience of various reasoning statements, each representing 1 of the 7 social influences. No (...) single source of ethical guidance appeared; in many cases different influences emerge as powerful under different circumstances. But of the 7 proposed influences, 5 showed consistent strength in predicting the decision the journalist makes. The individual influence was the weakest of the 7, despite its prominent strength in the literature. The organizational and small-group strength suggests company-level strategies for media policy-makers who wish to increase journalists'ethical awareness. Overall, the study seems to challenge a traditional assumption that in ethical dilemmas journalists are autonomous moral agents, acting on the basis of their own values alone. The data support the notion of a far more dynamic and complex pattern of social influences. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Examining the Ethics of Human Subjects ResearchPaul S. Appelbaum (bio)The work of the Advisory Committee on Human Radiation Experiments confirms once again the value of combining empirical and normative approaches to problems in clinical and research ethics. The Committee, like its predecessor, the President’s Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, spent relatively modest sums of money gathering targeted data to inform (...) its deliberations. The results of the Committee’s research, which are discussed by Nancy Kass and Jeremy Sugarman in this issue of the Kennedy Institute of Ethics Journal, enhance our understanding of the current ethical status of human subjects research, helping to focus attention on areas of particular concern, and lay the basis for future research and policy development.My comments here focus on the two major empirical studies conducted by the Committee—the Research Proposal Review Project and the Subject Interview Study. I will underscore just a few of the primary findings from these studies, consider their limitations, and explore their implications. Readers interested in the details of the studies should consult the Committee’s Final Report (ACHRE 1995), on which I rely in part and which provides additional information on the methodology and findings of the studies.Research Proposal Review ProjectWhat can be learned from the Committee’s review of 125 federally-funded human research studies? In answering that question, one cannot ignore the irony inherent in the Committee’s decision to review documents related to institutional review board (IRB) consideration of the selected protocols. The single most frequent complaint about the current system for protecting human subjects is that IRBs focus almost exclusively on review of consent forms and other research documents, as if they bore some close relationship to what actually transpires between investigators and potential research subjects. Only a small number of studies examine the research consent process. Nevertheless, existing data strongly [End Page 283] suggest that subject recruitment often involves an extended process of courtship, during which the information contained in consent forms is only a small part of the information passed between investigators and subjects (Benson, Roth, and Winslade 1985; Lidz et al. 1984).Indeed, the second of the Committee’s studies—the Subject Interview Study, which is discussed below—appears to confirm these findings. In-depth interviews with 99 individuals who reported that they were former or current research subjects suggest that “[f]or many, the decision to participate seemed to have been made before the consent form was given to them, and they signed it almost as a formality” (ACHRE 1995 [GPO, p. 742; Oxford, p. 471]). 1 Why, then, did the Committee focus its attention on documents that in many cases seem to play only a tangential role in the consent process? As is the case with IRBs around the country, the answer appears to be that consent forms and related documents are the only easily available window on consent transactions. In addition, under the current system, consent forms constitute the part of the process that IRBs can influence most easily. Consequently, it suits almost everyone’s needs—except perhaps those of the research subjects—to pretend that they reflect what actually transpires in the recruitment process. To the Committee’s credit, it was well aware of this dilemma. Nonetheless, it struggled to wring valid lessons from these limited data in its Final Report.Perhaps the most interesting finding from the Research Proposal Review Project is just how poor so many consent forms are. Given the disproportionate emphasis that many IRBs place on the content of the forms, one would expect that investigators by now would have learned to design documents that meet objective standards of adequacy, such as those applied by the Committee. Indeed, except in the most unusual circumstances, doing so would virtually guarantee that the IRB will ask no further questions about subject recruitment procedures. Although the data justify the inference that many investigators do not yet understand which information is essential to communicate to potential subjects, nor have learned how to do so effectively, they also force us to a still more radical conclusion. If the IRBs were doing their jobs, the Committee... (shrink)

Background The use of lengthy, detailed, and complex informed consent forms is of paramount concern in biomedical research as it may not truly promote the rights and interests of research participants. The extent of information in ICFs has been the subject of debates for decades; however, no clear guidance is given. Thus, the objective of this study was to determine the perspectives of research participants about the type and extent of information they need when they are invited to participate in (...) biomedical research. Methods This multi-center, cross-sectional, descriptive survey was conducted at 54 study sites in seven Asia-Pacific countries. A modified Likert-scale questionnaire was used to determine the importance of each element in the ICF among research participants of a biomedical study, with an anchored rating scale from 1 to 5. Results Of the 2484 questionnaires distributed, 2113 were returned. The majority of respondents considered most elements required in the ICF to be ‘moderately important’ to ‘very important’ for their decision making. Major foreseeable risk, direct benefit, and common adverse effects of the intervention were considered to be of most concerned elements in the ICF. Conclusions Research participants would like to be informed of the ICF elements required by ethical guidelines and regulations; however, the importance of each element varied, e.g., risk and benefit associated with research participants were considered to be more important than the general nature or technical details of research. Using a participant-oriented approach by providing more details of the participant-interested elements while avoiding unnecessarily lengthy details of other less important elements would enhance the quality of the ICF. (shrink)

For every partial combinatory algebra, we define a hierarchy of extensionality relations using ordinals. We investigate the closure ordinals of pca’s, i.e., the smallest ordinals where these relations become equal. We show that the closure ordinal of Kleene’s first model is ${\omega _1^{\textit {CK}}}$ and that the closure ordinal of Kleene’s second model is $\omega _1$. We calculate the exact complexities of the extensionality relations in Kleene’s first model, showing that they exhaust the hyperarithmetical hierarchy. We also discuss embeddings of (...) pca’s. (shrink)

Issues of interest, identity and values intertwine in environmental conflicts, creating challenges that cannot generally be overcome using rationalities grounded in generalised argumentation and abstraction. To address the growing need to engage interests and identities along with plural values in the conservation of biodiversity and ecological systems, we introduce the concept of ‘appropriateness of actions’ and ground it in a relational understanding of environmental ethics. A determination of appropriateness for actions comes from combining outputs from value elicitation with those of (...) interest and identity negotiation in ways that are salient to specific people and their relationships to specific places. Drawing on the Blue Mountain Forest Partnership in the Pacific Northwest, we propose factors of success for supporting appropriate actions: 1) understanding context and identifying key stakeholders; 2) surfacing a diversity of interests and building system-level trust; 3) building empathy for different identities grounded in specific places; 4) eliciting diverse values and seeking to understand their links to worldviews and knowledge systems and; 5) seeking out appropriate actions. (shrink)

How do journalists sort out the tangle of legal rights and ethical responsibilities in their everyday news work? A survey of 1,037 journalists and in-depth interviews with 22 others, found substantial evidence for 3 models of the relation of law and ethics: a Separate Realms model, a Correspondence model, and a new "Responsibility Model" in which the law is considered in problematic situations but only as one of several considerations in what is essentially an ethical decision. The findings have implications (...) for the maintenance of generous levels of First Amendment freedom news media currently enjoy. (shrink)

Objective Although patients exercise greater autonomy than in the past, and shared decision making is promoted as the preferred model for doctor-patient engagement, tensions still exist in clinical practice about the primary locus of decision-making authority for complex, scarce, and resource-intensive medical therapies: patients and their surrogates, or physicians. We assessed physicians’ attitudes toward decisional authority for adult venoarterial extracorporeal membrane oxygenation (VA-ECMO), hypothesizing they would favor a medical locus. Design, Setting, Participants A survey of resident/fellow physicians and internal medicine (...) attendings at an academic medical center, May to August 2013. Measurements We used a 24-item, internet-based survey assessing physician-respondents’ demographic characteristics, knowledge, and attitudes regarding decisional authority for adult VA-ECMO. Qualitative narratives were also collected. Main Results A total of 179 physicians completed the survey (15 percent response rate); 48 percent attendings and 52 percent residents/ fellows. Only 32 percent of the respondents indicated that a surrogate’s consent should be required to discontinue VA-ECMO; 56 percent felt that physicians should have the right to discontinue VA-ECMO over a surrogate’s objection. Those who self-reported as “knowledgeable” about VA-ECMO, compared to those who did not, more frequently replied that there should not be presumed consent for VA-ECMO (47.6 percent versus 33.3 percent, p = 0.007), that physicians should have the right to discontinue VAECMO over a surrogate’s objection (76.2 percent versus 50 percent, p = 0.02) and that, given its cost, the use of VA-ECMO should be restricted (81.0 percent versus 54.4 percent, p = 0.005). Conclusions Surveyed physicians, especially those who self-reported as knowledgeable about VA-ECMO and/or were specialists in pulmonary/ critical care, favored a medical locus of decisional authority for VA-ECMO. VA-ECMO is complex, and the data may (1) reflect physicians’ hesitance to cede authority to presumably less knowledgeable patients and surrogates, (2) stem from a stewardship of resources perspective, and/or (3) point to practical efforts to avoid futility and utility disputes. Whether these results indicate a more widespread reversion to paternalism or a more circumscribed usurping of decisional authority occasioned by VA-ECMO necessitates further study. (shrink)

Social expectations guide people's evaluations of others’ behaviors, but the origins of these expectations remain unclear. It is traditionally thought that people's expectations depend on their past observations of others’ behavior, and people harshly judge atypical behavior. Here, we considered that social expectations are also influenced by a drive for reciprocity, and people evaluate others’ actions by reflecting on their own decisions. To compare these views, we performed four studies. Study 1 used an Ultimatum Game task where participants alternated Responder (...) and Proposer roles. Modeling participants’ expectations suggested they evaluated the fairness of received offers via comparisons to their own offers. Study 2 replicated these findings and showed that observing selfish behavior (lowball offers) only promoted acceptance of selfishness if observers started acting selfishly themselves. Study 3 generalized the findings, demonstrating that they also arise in the Public Goods Game, emerge cross‐culturally, and apply to antisocial punishment whereby selfish players punish generosity. Finally, Study 4 introduced the Trust Game and showed that participants trusted players who reciprocated their behavior, even if it was selfish, as much as they trusted generous players. Overall, this research shows that social expectations and evaluations are rooted in drives for reciprocity. This carries theoretical implications, speaking to a parallel in the mechanisms driving both decision‐making and social evaluations, along with practical importance for understanding and promoting cooperation. (shrink)

Medicine has historically been slow to adopt new technologies. Although telepsychiatry was already to some degree in use before the COVID-19 pandemic, the imposed limitations on person-to-person contacts accelerated its growth exponentially. Outcome studies have generally supported telepsychiatry’s use,1 but the breathtaking rapid shift from in-person to video visits across psychiatry has occurred prior to more in-depth examinations on the fundamental changes to the nature of the patient–physician interface. In their paper: “Can you hear me?”: communication, relationship and ethics in (...) video-based telepsychiatric consultations’, the authors aptly take this deep dive, carefully parsing out the potential areas of change from live visits to virtual sense by sense. The authors describe the sensory and spatial context of psychiatric consultation, where vision, hearing and even smell play a role in the assessment of the patient. Furthermore, they consider multiple aspects around telepsychiatric consultations, including technical and educational components for patients and clinicians, and highlight the ethical dimensions of a psychiatric consultation under this new model.2 How many clinical clues might a …. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

Although hope is a pervasive concept in cancer treatment, we know little about how ambulatory patients with cancer define or experience hope. We explored hope through semistructured interviews with ten patients with advanced (some curable, some incurable) colon cancer at one Midwestern, university–based cancer center. We conducted a thematic analysis to identify key concepts related to patient perceptions of hope. Although we did ask specifically about hope, patients also often revealed their hopes in response to indirect questions or by telling (...) stories about their cancer experience. We identified four major themes related to hope: 1) hope is essential, 2) a change in perspective, 3) the content of hope, and 4) communicating about hope. The third theme, the content of hope, included three subthemes: a) the desire for normalcy, b) future plans, and c) hope for a cure. We conclude that hope is an essential concept for patients undergoing treatment for cancer as it pertains to their psychological well–being and quality of life, and hope for a cure is not and should not be the only consideration. In a clinical context, the exploration of patients’ hopes and aspirations in light of their cancer diagnosis is important because it provides a frame for understanding their goals for treatment. Exploration of the content of patients’ hope can not only help to illuminate misunderstandings but also clarify how potential treatments may or may not contribute to achieving patients’ goals. (shrink)

We applaud Norris et al.'s critical review of the literature on lexical effects in phoneme decision making, and we sympathize with their attempt to reconcile autonomous models of word recognition with current research. However, we suggest that adaptive resonance theory (ART) may provide a coherent account of the data while preserving limited inhibitory feedback among certain lexical and sublexical representations.

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

Like other Arab countries, Jordan must find ways of responding to the rapid processes of change affecting many aspects of social life. This is particularly urgent in healthcare, where social and technical change is often manifested in tensions about ethical decision-making in the clinic. To explore the attitudes, beliefs and concerns relating to ethical decision-making among health professionals in Jordanian hospitals, a qualitative study was conducted involving face-to-face interviews with medical personnel in four hospitals in Amman, the capital of Jordan. (...) Data were analysed thematically in relation to a pre-existing set of ethical categories. Interviews were conducted with thirty-eight doctors covering most medical specialities. Five major themes emerged from the interviews: ethical awareness, ethical issues, the impact of religion on ethical decision-making, practical and theoretical resources for ethical decision-making, and challenges. While uncertainty was expressed about some aspects of Western approaches to ethics, participants strongly supported adoption of a range of Western bioethical principles, including cultural and ethical diversity, along with adherence to Islamic religious norms. A range of serious ethical challenges facing the Jordanian health system were identified, covering social, legal, managerial, and technical issues. Ethical decision-making in Jordan is complex, having to accommodate the needs of patients, the opinions of doctors and their families, the views of religious authorities, managerial considerations, and both local norms and international standards. Health professionals struggle with three sets of tensions that emerge out of the struggle between traditional, community-embedded forms of social organization and the demands generated by globalization and the influence of Western culture: the tensions between tradition and modernity, conservatism and pragmatism, and religion and secularism. Doctors in Jordan prefer approaches to ethical decision-making that realize a balance between the extremes, although the exact nature of where that balance should lie remains uncertain. (shrink)

High-spin states have been studied in Pr-135(59), populated through the Cd-116(Na-23,4n) reaction at 115 MeV, using the Gammasphere gamma-ray spectrometer. The negative-parity yrast band has been significantly extended to spin similar to 45 (h) over bar and excitation energy 21.5 MeV, showing evidence for several rotational alignments. The positive-parity yrast band of Ce-135(58), populated through the p4n channel of this reaction, was also populated to spin similar to 38 (h) over bar and excitation energy 18 MeV. Cranking calculations indicate that (...) these nuclei are soft with respect to the triaxiality parameter gamma and that several competing nuclear shapes occur at high spin. (shrink)

Contents: Acknowledgements. Conventions. Preface. Biographical sketch. 1 Introduction. 2 The Contributions. 3 Early work in analysis. 4 The Theory of Science . 5. Later mathematical studies. A On Kantian Intuitions. B The Bolzano-Cauchy Theorem.

There are, by now, many rival, sophisticated philosophical accounts of causation that qualify as ‘metaphysically reductive’. This is a good thing: these collective efforts have vastly improved our understanding of causation over the last 30 years or so. They also put us in an excellent position to reflect on some central methodological questions: What exactly is the point of offering a metaphysical reduction of causation? What philosophical scruples ought to guide the pursuit of such a reduction? Finally, how should answers (...) to these latter questions affect one’s assessment of the main contemporary approaches? That’s what we investigate in this essay. Section 1 lays out our presuppositions. Section 2 reviews a sample of philosophical accounts. Then comes the main event: Section 3 looks in detail at the foregoing methodological questions, closing with a reconsideration of our sample accounts, in light of what we’ve found. (shrink)

The emergence of new obstetrical and neonatal technologies, as well as more aggressive clinical management, has significantly improved the survival of extremely low birth weight infants. This development has heightened concerns about the limits of viability. ELBW infants, weighing less than 1,000 grams and no larger than the palm of one's hand, are often described as of late twentieth century technology. Improved survivability of ELBW infants has provided opportunities for long-term follow-up. Information on their physical and emotional development contributes to (...) developing standards of practice regarding their care. (shrink)

Li Zehou is perhaps best known among Western audiences for his work on aesthetics. This is mainly due to the fact that translations of his writings available in English are mostly limited to his aesthetics.1 The content of A Response to Michael Sandel and Other Matters differs greatly from these previous translations. Published in Chinese in 2014, it is one of Li’s most recent books, and in it he discusses several main points of the systematic philosophical outlook he has developed (...) over recent decades, and places them in relation to Western liberalism. A Response thus aims far beyond responding to Michael Sandel’s views on justice and morality as presented in the... (shrink)

Hypocretin regulates brain reward function and cocaine consumption in rats. The hypocretinergic (Hcrt) system is implicated in energy homeostasis, feeding and sleep regulation. Hypocretinergic cell bodies are located in the lateral hypothalamus (LH) and project throughout the brain. The aim of the present studies was to investigate the role of the Hcrt system in regulating brain reward function and the reinforcing properties of cocaine in rats. Intracranial self-stimulation (ICSS) thresholds provide an accurate measure of brain reward function in rats. Here (...) we show that a single injection of Hcrt-1 (5 µg icv) induced persistent, long-lasting elevations in ICSS thresholds in drug-naïve rats. Indeed, Hrct-1 elevated ICSS thresholds for 36 h, with peak elevations between 6 and 12 hours after injection. Hrct-1-induced threshold elevations were attenuated by an antibody known to neutralize the binding of hcrt-1 to its receptors. Taken together, these observations suggest that Hrct-1 negatively regulates brain reward function in rats. Because Hrct-1 negatively regulates brain reward function, we hypothesized that it may attenuate the increased brain reward function usually observed after cocaine consumption, and thereby alter cocaine self-administration behavior. A daily injection of Hrct-1 (1 µg icv), for 4 consecutive days, slightly increased cocaine self-administration (0.25 mg/infusion) in rats. Overall, these data demonstrate that Hrct-1 negatively regulates brain reward function, and as such may indirectly alter cocaine self-administration. Given the well-established role of hypocretin neurons in regulating feeding behavior and sleep, we hypothesize that hypocretinergic regulation of brain reward function may provide a mechanism by which appropriate and competing behaviors (e.g. sleep or feeding) may be engaged to maintain energy homeostasis. (shrink)

I hope to show that supervenience and determination, as I have here intuitively characterized them, are really different expressions of the same core idea which one may make more precise in a great number of different ways, depending on the interpretation one puts on the catchall parameters “cases”, “truth of kind P”and “truth of kind S”.